MARYLAND TECHNOLOGY ENTERPRISE INSTITUTE

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PATHS FOR MARYLAND  ENTREPRENEURS & INNOVATORS

 

BIOTECHNOLOGY RESEARCH AND EDUCATION PROGRAM

BREP > BIOPROCESS SCALE-UP FACILITY

Overview

Founded in 1985, The Bioprocess Scale-Up Facility (BSF) is the Biotechnology Research and Education Program's modern bioprocessing laboratory dedicated to the development and scale-up of fermentation biotechnology products and processes, specifically bacteria and yeast. With over 1500 fermentations conducted since 1998, the BSF has accelerated the R&D of local biotechnology leaders such as MedImmune and Martek, and provided supplemental support the research of various US government agencies including  Edgewood Chemical Biological Center, USDA and the NIH.

Our capabilities include:

  • Fermentation
  • Separation
  • Purification
  • Product analysis
  • Challenging problems such as biopolymers, turbulence and multiphase fluid dynamics, biosensors, process analysis and control, and both metabolic and biochemical engineering.

Advantages of the BSF:

The BSF enables small manufacturing companies to offer extended capabilities to major pharmaceutical (Big Pharma) companies out-of-state

Production processes are directly transferable to partners operating under cGMPs (required for FDA-approved clinical trials), such as Paragon Bioservices and Advanced Bioscience Labs

A unique facility in Maryland not restricted by current good manufacturing practices (cGMP) requirements

100% of undergraduates employed by the BSF go on to work in the  Biotech industry following graduation

 

Private Companies

Federal Government

Academic

3-Dimension Pharmaceuticals

Action Products, Inc. (Hagerstown)

Advanced BioScience Laboratories, Inc. (Kensington)

Advanced BioNutrition (Columbia)

Athena Environmental Sciences Inc. (Baltimore)

Atto Instruments, Inc. (Rockville)

Brassica, Inc. (Baltimore)

Becton Dickinson Microbiology Systems (Cockeysville)

Bioscience Contract Production Corporation (Baltimore)

Biosys Inc. (Columbia)

Biospherics, Inc. (Beltsville)

Biotechnology Research Labs, Inc. (Rockville)

Cambrex (Walkersville)

Cambrex (Baltimore)

CarboMed

Cell Trends, Inc. (Middletown)

Chesapeake Biologicals (Baltimore)

Chesapeake PERL (Savage)

Chitin Works, Inc. (Cambridge)

Claragen, Inc. (College Park)

Crop Genetics International, Inc. (Columbia)

Digene Corporation (Gaithersburg)

Dynagen, Inc.

EntreMed, Inc. (Rockville)

Environmental Elements, Inc. (Baltimore)

Enzion, Inc.

Gene Logic, Inc. (Rockville)

Human Genome Sciences, Inc. (Rockville)

ID Biomedical

Igen, Inc. (Rockville)

Igene, Inc. (Columbia)

Instrument Research Company, Inc. (Columbia)

Innovative Biosensors (College Park)

IOMAI (Gaithersburg)

ISP Mineral Products, Inc. (Hagerstown)

Kemp Biotechnologies, Inc. (Frederick)

LifeTechnologies/BRL/Gibco, Inc. (Rockville)

Magenta, Inc. (Baltimore)

Martek Biosciences Corp. (Columbia)

MedImmune, Inc. (Gaithersburg)

Meso-Scale

Microbiological Associates (Rockville)

Midland Reagent Company

Molecular Oncology, Inc. (Gaithersburg)

New Earth Sciences, Inc. (Cambridge)

New York Blood Center

Oceanix (Baltimore)

Oncologix, Inc. (Rockville)

OncoImmunin, Inc. (College Park)

Oncor, Inc. (Gaithersburg)

Organon Technica

Orphan Medical

Paragon Biotech, Inc. (Baltimore)

PerImmune, Inc. (Rockville)

Procter & Gamble (Baltimore)

Proneuron Co. (Rockville)

Proteinix, Inc. (Rockville)

Prozyme, Inc.

Puresyn, Inc

SRCHEM, Inc. (Elkridge)

Ventenna Medical Systems (Gaithersburg)

Wheaton Science

National Institutes of Health

 

National Institute of Standards and Technology

 

Naval Research Laboratory

 

US Army, Edgewood Research Development and Engineering Center (ERDEC)

 

US Army, Walter Reed Research Institute

 

United States Department of Agriculture, Beltsville, MD, Martinsburg, WV

University of Maryland

Center for Vaccine Development

Animal Science

Biochemistry

Microbiology

Cell Biology and Molecular Genetics

University of Maryland Biotechnology Institute

MBC

COMB

CARB

CBR

University of Virginia

Duke Medical

Ain Shams University, Cairo

The University of Trieste

University of California, Irvine

Companies and Labs Utilizing the BSF

In addition to the preceding, the BSF has provided education/ training courses to the following:

 

  • Science Applications International Corporation (SAIC)
  • CIA University
  • MedImmune, Gaithersburg, MD
  • University of Maryland Undergraduate Classes: BSCI 223, BSCI 288, ENCH 437, ENCH 482, ENCH 648, ENBE 489, ENBE 499
  • University of Maryland Fermentation Workshop
  • University of Maryland Purification Workshop

 

Contact Us

 

Kevin Knapstein

BSF Manager

(301) 314-7806

kknaps@umd.edu

Bioprocess Scale-Up Facility

1203 Chem./Nuc. Building #090

University of Maryland

College Park, MD 20742

 

 

 

2120 Potomac Bldg. 092

University of Maryland

College Park, MD 20742-3415

 

tel: 301.405.3906

fax: 301.403.4105

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