| |
The
Bioprocess Scale-Up Facility (BSF) is the Biotechnology
Research and Education Program's
modern bioprocessing laboratory dedicated to the development
and
scale-up of biotechnology
products and processes. With more than 678 fermentations
conducted since 1998 alone, the BSF has accelerated the
R&D of local
biotechnology leaders such as Human Genome Sciences,
NIH and MedImmune,
as well as growing Maryland start-ups such
as Martek Biosciences and Digene Corporation.
The
BSF's capabilities
include:
- Fermentation
- Cell
culture
- Separation
- Purification
- Product
analysis
- Challenging
problems such as biopolymers, turbulence and multiphase
fluid dynamics, biosensors, process
analysis and control, and both metabolic and biochemical engineering.
BSF
Advantages
- The
BSF is the only facility in Maryland available to both
small and large companies for projects
not restricted by current good manufacturing practices (cGMP) requirements
- Production
processes are directly transferable to partners operating
under cGMPs (required
for FDA-approved clinical trials), such as Cambrex Inc. and the Walter Reed
Army Institute
of Research
- The
BSF enables small manufacturing companies to offer extended
capabilities
to major pharmaceutical
(Big Pharma) companies out-of-state
- BSF
researchers are some of the best in Maryland: the last
seven BSF graduates were each
offered jobs at Human Genome Sciences
BSF
Equipment
- Bioreactors
from 2 to 250 Liters
- Process
centrifuges
- Cell
disruption
- Tangential
flow filtration
- Chromatography
- Freeze
drying
Companies and Government Labs Utilizing the BSF
Private
Companies
- 3-Dimension
Pharmaceuticals
- Action
Products, Inc. (Hagerstown)
- Advanced
BioScience Laboratories, Inc. (Kensington)
- Advanced
BioNutrition (Columbia)
- Athena
Environmental Sciences Inc. (Baltimore)
- Atto
Instruments, Inc. (Rockville)
- Brassica,
Inc. (Baltimore)
- Becton
Dickinson Microbiology Systems (Cockeysville)
- Bioscience
Contract Production Corporation (Baltimore)
- Biosys
Inc. (Columbia)
- Biospherics,
Inc. (Beltsville)
- Biotechnology
Research Labs, Inc. (Rockville)
- Cambrex
(Walkersville)
- Cambrex
(Baltimore)
- CarboMed
- Cell
Trends, Inc. (Middletown)
- Chesapeake
Biologicals (Baltimore)
- Chesapeake
PERL (Savage)
- Chitin
Works, Inc. (Cambridge)
- Claragen,
Inc. (College Park)
- Crop
Genetics International, Inc. (Columbia)
- Digene
Corporation (Gaithersburg)
- Dynagen,
Inc.
- EntreMed,
Inc. (Rockville)
- Environmental
Elements, Inc. (Baltimore)
- Enzion,
Inc.
- Gene
Logic, Inc. (Rockville)
- Human
Genome Sciences, Inc. (Rockville)
- ID
Biomedical
- Igen,
Inc. (Rockville)
- Igene,
Inc. (Columbia)
- Instrument
Research Company, Inc. (Columbia)
- Innovative
Biosensors (College Park)
- IOMAI
(Gaithersburg)
- ISP
Mineral Products, Inc. (Hagerstown)
- Kemp
Biotechnologies, Inc. (Frederick)
- LifeTechnologies/BRL/Gibco,
Inc. (Rockville)
- Magenta,
Inc. (Baltimore)
- Martek
Biosciences Corp. (Columbia)
- MedImmune,
Inc. (Gaithersburg)
- Meso-Scale
- Microbiological
Associates (Rockville)
- Midland
Reagent Company
- Molecular
Oncology, Inc. (Gaithersburg)
- New
Earth Sciences, Inc. (Cambridge)
- New
York Blood Center
- Oceanix
(Baltimore)
- Oncologix,
Inc. (Rockville)
- OncoImmunin,
Inc. (College Park)
- Oncor,
Inc. (Gaithersburg)
- Organon
Technica
- Orphan
Medical
- Paragon
Biotech, Inc. (Baltimore)
- PerImmune,
Inc. (Rockville)
- Procter & Gamble
(Baltimore)
- Proneuron
Co. (Rockville)
- Proteinix,
Inc. (Rockville)
- Prozyme,
Inc.
- Puresyn,
Inc
- SRCHEM,
Inc. (Elkridge)
- Ventenna
Medical Systems (Gaithersburg)
- Wheaton
Science
Federal
Government:
- National
Institutes of Health
- National
Institute of Standards and Technology
- Naval
Research Laboratory
- US
Army, Edgewood Research Development and Engineering
Center (ERDEC)
- US
Army, Walter Reed Research Institute
- United
States Department of Agriculture, Beltsville, MD, Martinsburg,
WV
Academic
- University
of Maryland
- Center
for Vaccine Development
- Animal
Science
- Biochemistry
- Microbiology
- Cell
Biology and Molecular Genetics
- University
of Maryland Biotechnology Institute
- University
of Virginia
- Duke
Medical
- Ain
Shams University, Cairo
- The
University of Trieste
- University
of California, Irvine
In
addition to the preceding, the BSF has provided
education/ training courses to the following:
- Science
Applications International Corporation (SAIC)
- CIA
University
- MedImmune,
Gaithersburg, MD
- University
of Maryland Undergraduate Classes: BSCI 223, BSCI 288,
ENCH 437, ENCH 482, ENCH 648, ENBE 489, ENBE 499
- University
of Maryland Fermentation Workshop
- University
of Maryland Purification Workshop
 Read
about BREP success stories
|
|
